Santiago has been suspended for 80 games after testing positive for exogenous testosterone, in violation of MLB's Joint Drug Prevention and Treatment program, Mark Feinsand of MLB.com reports.

EDGE Analysis

Santiago faced a 10-game ban earlier in the season for having a foreign substance on his glove. He'll now face a lengthier suspension and will not appeal. Santiago should be able to serve about 55 games of the suspension by the end of the campaign, meaning he could be reinstated at some point in May of the 2022 season.

Santiago (suspension) fired two innings in a loss to the Astros on Tuesday, allowing an earned run on four hits and a walk.

EDGE Analysis

The veteran southpaw made his return after the completion of his 10-game MLB suspension. Santiago was put right back to work in the multi-inning role he's typically been deployed in this season and should be set for regular long-relief work again moving forward.

The Mariners reinstated Santiago to the active roster Tuesday after he completed his 10-game suspension.

EDGE Analysis

Santiago's suspension stemmed from his ejection in a June 26 appearance versus the White Sox after officials spotted a foreign substance on his glove. Before his suspension went into effect July 15, Santiago had been working as a starter for Seattle, but it's unclear whether he'll now slot back into a starting role or move to the bullpen. If the Mariners do decide to deploy Santiago in the rotation, he would likely replace Darren McCaughan, who was touched up for seven runs in four innings in the Mariners' come-from-behind victory Monday.

Santiago's 10-game suspension was upheld Thursday, Jeff Passan of ESPN.com reports.

EDGE Analysis

Santiago was ejected from a game in late June for having a foreign substance on his glove, but he was able to pitch while appealing his suspension. However, he'll serve the full length of his suspension following the All-Star break, and the Mariners will have to play with a shorthanded roster for the next 10 games. The southpaw will be eligible to return July 27 against the Astros.

Santiago allowed one run on two hits and a walk while striking out one over three innings Sunday against the Angels. He did not factor into the decision.

EDGE Analysis

Santiago made his first start of the season due to the Mariners dealing with a number of injuries to their rotation. The veteran southpaw had a clean first two innings but allowed a solo home run in the third to David Fletcher to tie the game. He now owns a 3.33 ERA, 1.36 WHIP and 29L10 K:BB over 24.1 innings. The 33-year-old is expected to hear the result of the appeal this week for his 10-game suspension for having a foreign substance on his glove in late June. If the suspension is upheld, the Mariners will be down another arm and will be scrambling for some starting pitching coming out of the All-Star break.

Seattle manager Scott Servais said Santiago will start Sunday's game against the Angels, Ryan Divish of The Seattle Times reports.

EDGE Analysis

With Justus Sheffield (forearm) and Justin Dunn (shoulder) recently joining James Paxton (elbow), Nick Margevicius (shoulder) and Ljay Newsome (elbow) on the injured list, the Mariners have been forced to shorten their rotation from six to five men. Santiago will pick up his first start of the season as a replacement for Sheffield, and the veteran southpaw should have a decent amount of leash, despite working out of the bullpen all season. He most recently tossed a season-high 76 pitches in a long-relief Tuesday against the Yankees, giving up three runs on seven hits and two walks over 3.1 innings.

Santiago, who's currently appealing his 10-game suspension for allegedly having a foreign substance on his glove, fired a scoreless eighth inning in an extra-inning win over the Rangers on Friday, allowing one hit and recording three strikeouts.

EDGE Analysis

The veteran southpaw seemingly came out on a mission Friday, and with his trio of strikeouts, he ran his K:BB to an excellent 26:7 across 18 innings for the season. The appearance was Santiago's first since his glove was inspected as he wrapped up a 2.1-inning appearance against the White Sox last Saturday.

Santiago was handed a 10-game suspension Tuesday for having a foreign substance on his glove during Sunday's game against the White Sox, Jeff Passan of ESPN.com reports. He will appeal and remain on the 26-man roster until the league makes a final decision.

EDGE Analysis

Santiago became the first player to get ejected for a foreign substance under the new protocols. Per Jesse Rogers of ESPN.com, the league didn't inspect Santiago's glove after it was confiscated and the suspension was purely based on the umpires' report. The southpaw's appeal means that he'll remain on the 26-man roster for the time being, but if the ruling is upheld, Seattle will be forced to play a man down for 10 games.

Santiago was ejected in the bottom of the fifth inning during Sunday's game against the White Sox because of a foreign substance on his glove, Jeff Passan of ESPN.com reports. He allowed one run on three hits and two walks before departing.

EDGE Analysis

Santiago becomes the first pitcher to get tossed under the new foreign substance rules that were instituted last week. While the southpaw will likely appeal, as of now he'll be suspended for the next 10 games, during which the Mariners will be forced to play with just 25 players.

Santiago (1-1) earned the win Thursday against the Rays after tossing a scoreless inning, striking out the three batters he faced.

EDGE Analysis

Santiago looked absolutely dominant, as he struck out the side and needed just 17 pitches to get the job done (11 strikes). The southpaw has made just seven appearances on the season and while he was hit hard in his debut, he's now recorded five straight scoreless outings.