Santana did not make the Royals' Opening Day roster, Anne Rogers of MLB.com reports.

EDGE Analysis

The 38-year-old right-hander seemed like a candidate for long relief during spring training, but Santana wasn't included on the 26-man roster. He signed a minor-league deal with the Royals in December, so he could bide his time at the alternate training site or Triple-A Omaha once the minor-league season begins.