Niese left Tuesday's game against the Cardinals in the first inning with an apparent injury, Anthony DiComo of MLB.com reports.

EDGE Analysis

He faced four batters before leaving the field with a team trainer (21 pitches). It wasn't obvious what was ailing Niese, but he came into the game battling knee soreness and this is presumably related. Robert Gsellman replaced Niese on the mound with one out in the first inning.