How can I delete a week in the schedule?

Commissioners can remove match-ups for a week so that it's a "bye week" of sorts for the entire league. No fantasy games happen in your league that week, so no owners can be affected negatively. Here are the steps to take (best followed on a desktop computer):

Go to League >> Settings >> Edit Regular Season Schedule >> Custom
Choose the week you want to make a bye week in the date selector drop-down
Drag and drop each team from the left Match-ups column to the "Not Playing" box on the right
When the left column is completely empty, click Save at the bottom